We are happy to present the joining of Xiaobo Zhao as our newest member of HASTE. Xiaobo Zhao is joining the group of Andreas Hellander to work as a PostDoctoral Researcher. Xiaobo will be working on research and development of intelligent stream data processing pipelines, and the development of intelligent and efficient cloud systems capable of mapping data and compute to a variety of cloud computing and data storage e-infrastructure based on the quality and interestingness of the data.
Xiaobo Zhao received the M.S. degree in Communications and Information System from Northwestern Polytechnical University, Xi’an, China in 2015. He later received a Ph.D. degree in Electrical and Computer Engineering from Aarhus University, Aarhus, Denmark in 2020. Before joining the Hellander lab, he was a Research Assistant at Aarhus University and focused on efficient ML/DL service offloading to Edge/Cloud servers.
We are happy to announce that our paper “Deep learning models for lipid-nanoparticle-based drug delivery” is now available ahead of print and open access in the journal Nanomedicine.
Authors: Harrison PJ, Wieslander H, Sabirsh A, Karlsson J, Malmsjö V, Hellander A, Wählby C & Spjuth O.
Abstract: Background: Early prediction of time-lapse microscopy experiments enables intelligent data management and decision-making. Aim: Using time-lapse data of HepG2 cells exposed to lipid nanoparticles loaded with mRNA for expression of GFP, the authors hypothesized that it is possible to predict in advance whether a cell will express GFP. Methods: The first modeling approach used a convolutional neural network extracting per-cell features at early time points. These features were then combined and explored using either a long short-term memory network (approach 2) or time series feature extraction and gradient boosting machines (approach 3). Results: Accounting for the temporal dynamics significantly improved performance. Conclusion: The results highlight the benefit of accounting for temporal dynamics when studying drug delivery using high-content imaging.
In the figure below we show a schematic for the modelling approach used in the paper that combined convolutional and recurrent neural networks (long short-term memory, LSTM). This model is used for predicting information only present in the GFP channel at the end of the experiment from other imaging channels captured during the early time points of the experiment, prior to any GFP expression.
Following the win at the Adipocyte Imaging Challenge organized by AstraZeneca, two PhD students from the team, Ankit Gupta, and Håkan Wieslander were asked to comment in a technical report in Nature on the topic of virtual staining.
Fluorescence imaging is a valuable tool for biological analysis but is time-consuming and toxic to the cells. Using deep learning to virtually stain bright-field images is an active field of research that can alleviate these problems. Phil Harrison, a PhD student in the HASTE group, presented a poster at the Swedish Symposium on Deep Learning (SSDL) 2021 based on the HASTE team’s winning solution for the Adipocyte Cell Imaging Challenge. The poster presented our approach and results.
AI Sweden and AstraZeneca organised the Adipocyte Cell Imaging Challenge, a two-week-long hackathon to help AstraZeneca accelerate the drug development process. The task was to use machine learning in solving the problem of labelling cell images without requiring toxic preprocessing of cell cultures by predicting the content of the fluorescence images from the corresponding bright-field images.
The solution used the Learning Under Privileged Information (LUPI) paradigm to solve the problem. LUPI enables the inclusion of additional (privileged) information when training machine learning models, data that is not available when making predictions. In this case, the segmentation masks of the nuclei were used as the privileged information during the training of machine learning models. Our solution will help AstraZeneca to speed up the drug discovery process and bring drugs to market quicker.
Unfortunately, we didn’t get a chance to enjoy the good food and beautiful environment of the Noor Castle, but we had a productive project meeting anyway. The meeting started with report reading and Salman Toor presenting his docent lecture “Distributed Computing e-Infrastructures (DCI): Challenges and Opportunities for Application Experts and Service Providers”. This was followed by intense brainstorming on the continued research in the project, and a discussion on the almost complete half-time report, and planning for the coming Tuesday seminars, which have become an important part of the project communication now that most of us work from home.
Hongru is a master’s student from the department of statistics, and his main interests in statistics include multivariate statistical methods and Bayesian statistics.
Hongru’s MSc thesis will focus on developing the better hierarchical representations of the microscopy image data from cellular experiments with the help of statistical methods, focusing on improving readability and informational efficiency of the representation.
We welcome Tianru Zhang as new PhD Student in the Hellander lab at the Department of Information Technology, Uppsala University.
Tianru obtained his Bachelor in Probability and Statistics in Mathematics at the University of Science and Technology of China in 2017. Then, he completed his Master in Statistics for Smart Data at ENSAI (The National School of Statistics and Analysis of Information of France) in 2018. Before moving to Uppsala, he was employed as Assistant Researcher at the Fujitsu R&D center Co., Ltd. where he worked on developing DeepTensor (a deep learning method using tensor decomposition) and analyzing data of personal online loans.
Andrea is doing a traineeship at the Department of Information Technology – Division of Visual Information and Interaction, Uppsala University while coursing the last semester from the master’s in Medical Physics at the University of Eastern Finland.
Andrea’s internship project focus on developing an approach of registering and aggregating short exposure miniTEM images (superresolution reconstruction). The project objective is to achieve better quality and higher resolution image compare to a long exposure one.
We welcome Ebba Bergman as new PhD Student in the Spjuth lab at Department of Pharmaceutical Biosciences, Uppsala University.
Ebba obtained her Master of Science in Engineering, with a focus on bioinformatics, from Uppsala University in 2017. Before starting her PhD Ebba worked as a full-stack systems developer for 2 years.
About the PhD project within HASTE: Ebba is currently working on Conformal Prediction (CP) in combination with Convolutional Neural Networks. Next, she will focus on applying Learning Under Privileged Information (LUPI) on transmission electron microscopy data provided by Vironova. In general, Ebba will focus on combining machine learning methods with CP and LUPI using data provided by our HASTE-project partners.